Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | XDH | P47989 | 2/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.48 |
| ▸ | ABAT | P80404 | 1/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1308773 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4EMAPTTRPA1LMNA | |
| SCHEMBL1310214 | 0.91 | ALDH1A1 (0.75) | ALDH1A1KDM4EMAPTTRPA1LMNA | |
| SCHEMBL1310216 | 0.91 | ALDH1A1 (0.75) | ALDH1A1KDM4EMAPTTRPA1LMNA | |
| Cinnamaldehyde SCHEMBL10628048 | 0.87 | ALDH1A1 (0.86) | ALDH1A1KDM4EMAPTTRPA1LMNA | |
| Cinnamaldehyde SCHEMBL10631921 | 0.87 | ALDH1A1 (0.86) | ALDH1A1KDM4EMAPTTRPA1LMNA | |
| SCHEMBL5552912 | 0.86 | APP (0.55) | ALDH1A1KDM4EMAPTTRPA1LMNA | |
| SCHEMBL18921374 | 0.83 | FBP1 (0.49) | ALDH1A1KDM4EMAPTTRPA1LMNA | |
| SCHEMBL18921375 | 0.83 | FBP1 (0.49) | ALDH1A1KDM4EMAPTTRPA1LMNA | |
| SCHEMBL4195177 | 0.82 | CYP2A6 (0.58) | ALDH1A1KDM4ECYP2A6HSD17B10ALDH5A1 | |
| SCHEMBL9004502 | 0.82 | CYP2A6 (0.58) | ALDH1A1KDM4ECYP2A6HSD17B10ALDH5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053577-B2 | Derivatives of 5,9-methanocycloocta[b]pyridin-2-(1H)-one, their preparation and use as analgesics | ZHANG HESHENG | 2011-11-08 | — | — | US | disclosed |
| US-20090118320-A1 | DERIVATIVES OF 5,9-METHANOCYCLOOCTA[B]PYRIDIN-2-(1H)-ONE, THEIR PREPARATION AND USE AS ANALGESICS | ZHANG HESHENG | 2009-05-07 | — | — | US | disclosed |
| EP-2044937-A1 | ANALGESIC 5, 9 - METHANOCYCLOOCTA (b) PYRIDIN - 2 (1H) - ONE DERIVATIVES, THEIR PREPARATION METHOD AND USE | Tianjin Hemey Bio-Tech Co., Ltd. (CN) | 2009-04-08 | — | — | EP | disclosed |
| EP-1458679-A2 | PYRROLIDINE DERIVATIVES AS PROSTAGLANDIN MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003053923-A2 | PYRROLIDINE DERIVATIVES AS PROSTAGLANDIN MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-07-03 | — | — | WO | disclosed |
| EP-0912567-A1 | CARBOLINE DERIVATIVES | ICOS CORPORATION (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997043287-A1 | CARBOLINE DERIVATIVES | ICOS CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118320-A1 | DERIVATIVES OF 5,9-METHANOCYCLOOCTA[B]PYRIDIN-2-(1H)-ONE, THEIR PREPARATION AND USE AS ANALGESICS | CHRNA9, NR3C2, CBR3 | ALDH1A1 1806/4885KDM4E 3356/4885MAPT 3559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.