Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.31 |
| ▸ | INMT | O95050 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15920650 | 0.81 | UHRF1 (0.33) | EPHX2UHRF1CYP1A2CYP2A6 | |
| SCHEMBL30480839 | 0.78 | MEN1 (0.43) | MEN1ALDH1A1GAAKMT2ARYR2 | |
| SCHEMBL26535454 | 0.74 | UHRF1 (0.37) | MEN1GAAKMT2AUHRF1CYP1A2 | |
| SCHEMBL15691802 | 0.72 | MEN1 (0.48) | MEN1ALDH1A1GAAKMT2ARYR2 | |
| SCHEMBL5760741 | 0.72 | MEN1 (0.48) | MEN1ALDH1A1GAAKMT2ARYR2 | |
| SCHEMBL29471277 | 0.71 | PIM1 (0.49) | — | |
| SCHEMBL11981738 | 0.69 | DRD2 (0.41) | ALDH1A1UHRF1CYP1A2CYP2A6 | |
| SCHEMBL5758572 | 0.69 | GAA (0.55) | MEN1ALDH1A1GAAKMT2ARYR2 | |
| SCHEMBL19751453 | 0.69 | GAA (0.55) | MEN1ALDH1A1GAAKMT2ARYR2 | |
| SCHEMBL13089143 | 0.69 | ALDH1A1 (0.34) | MEN1ALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041145-B1 | AZATRICYCLIC COMPOUNDS AND THEIR USE | GLAXO GROUP LTD (GB) | 2010-10-27 | — | — | EP | disclosed |