Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2815267 | 0.81 | MAPK1 (0.51) | HTTTSHRMAPK1MEN1KMT2A | |
| SCHEMBL2376910 | 0.70 | MAPK1 (0.46) | HTTTSHRMAPK1MEN1KMT2A | |
| SCHEMBL11868217 | 0.70 | ALDH1A1 (0.49) | HTTTSHRMAPK1MEN1KMT2A | |
| SCHEMBL25625146 | 0.67 | MAPK1 (0.43) | HTTTSHRMAPK1MEN1KMT2A | |
| SCHEMBL31547920 | 0.67 | KDM4E (0.47) | HTTTSHRMAPK1MEN1KMT2A | |
| SCHEMBL2814964 | 0.66 | KMT2A (0.51) | HTTMAPK1MEN1KMT2AKDM4E | |
| SCHEMBL17163194 | 0.66 | GBA1 (0.43) | HTTMAPK1MEN1KMT2AKDM4E | |
| SCHEMBL25221709 | 0.66 | HTT (0.49) | HTTMAPK1MEN1KMT2AKDM4E | |
| SCHEMBL25626205 | 0.66 | L3MBTL1 (0.50) | HTTTSHRMAPK1MEN1KMT2A | |
| SCHEMBL11873039 | 0.65 | SMN1; SMN2 (0.64) | HTTTSHRMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2239261-A1 | PYRROLOPYRIMIDIN DERIVATIVE FOR USE AS PI3K INHIBITOR, AND USE THEREOF | Chugai Seiyaku Kabushiki Kaisha (JP) | 2010-10-13 | — | — | EP | disclosed |