Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL591470 | 0.86 | GBA1 (0.55) | GBA1FUCA1S1PR5BCHEACHE | |
| SCHEMBL17351179 | 0.86 | GBA1 (0.55) | GBA1FUCA1S1PR5BCHEACHE | |
| SCHEMBL13090657 | 0.85 | FUCA1 (0.50) | GBA1FUCA1S1PR5RORC | |
| SCHEMBL587335 | 0.85 | FUCA1 (0.50) | GBA1FUCA1S1PR5RORC | |
| SCHEMBL8171730 | 0.82 | FUCA1 (0.53) | FUCA1S1PR5CYP2C19SIGMAR1CTSL | |
| SCHEMBL13100615 | 0.82 | S1PR1 (0.41) | GBA1FUCA1S1PR5 | |
| SCHEMBL500382 | 0.79 | GBA1 (0.58) | GBA1FUCA1S1PR5 | |
| SCHEMBL500383 | 0.79 | GBA1 (0.58) | GBA1FUCA1S1PR5 | |
| SCHEMBL24652812 | 0.76 | FUCA1 (0.44) | FUCA1S1PR5CYP2C19SIGMAR1CTSL | |
| SCHEMBL21195952 | 0.76 | FUCA1 (0.44) | FUCA1S1PR5CYP2C19SIGMAR1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8940766-B2 | Methods for preventing and/or treating lysosomal storage disorders | AMICUS THERAPEUTICS, INC. (US) | 2015-01-27 | — | — | US | disclosed |
| US-8304429-B2 | Methods for preventing and/or treating degenerative disorders of the central nervous system | AMICUS THERAPEUTICS, INC. (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100261753-A1 | METHODS FOR PREVENTING AND/OR TREATING DEGENERATIVE DISORDERS OF THE CENTRAL NERVOUS SYSTEM | AMICUS THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100260740-A1 | METHODS FOR PREVENTING AND/OR TREATING LYSOSOMAL STORAGE DISORDERS | AMICUS THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261753-A1 | METHODS FOR PREVENTING AND/OR TREATING DEGENERATIVE DISORDERS OF THE CENTRAL NERVOUS SYSTEM | SNCA, BDNF, PARK7 | GBA1 71/4885FUCA1 727/4885S1PR5 72/4885 |
| US-20100260740-A1 | METHODS FOR PREVENTING AND/OR TREATING LYSOSOMAL STORAGE DISORDERS | GBA1, GAA, MAN2B1 | GBA1 1/4885FUCA1 156/4885S1PR5 274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.