Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | PARL | Q9H300 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTR1E | P28566 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9812380 | 0.87 | HSD17B10 (0.52) | HSD17B10ACHEALDH1A1RECQLMAPT | |
| SCHEMBL26218806 | 0.83 | MAPT (0.49) | HSD17B10ACHEALDH1A1RECQLMAPT | |
| SCHEMBL9110057 | 0.83 | HSD17B10 (0.48) | HSD17B10ACHEALDH1A1RECQLMAPT | |
| SCHEMBL26218807 | 0.81 | MAPT (0.48) | HSD17B10ACHEALDH1A1RECQLMAPT | |
| SCHEMBL23728176 | 0.79 | ALDH1A1 (0.49) | HSD17B10ACHEALDH1A1RECQLMAPT | |
| SCHEMBL16357119 | 0.79 | L3MBTL1 (0.48) | HSD17B10ACHEALDH1A1RECQLMAPT | |
| SCHEMBL23727719 | 0.77 | NPSR1 (0.45) | HSD17B10ACHEALDH1A1RECQLMAPT | |
| SCHEMBL15356035 | 0.77 | KMT2A (0.41) | ACHEALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL2876866 | 0.77 | PDE4A (0.41) | HSD17B10ACHEALDH1A1PARLMAPT | |
| SCHEMBL7810392 | 0.75 | MEN1 (0.63) | ALDH1A1RECQLKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1811998-B1 | TRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2010-10-20 | — | — | EP | disclosed |