Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13097730 | 0.96 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2MAPK10LMNAKMT2A | |
| SCHEMBL13097836 | 0.87 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2MAPK10LMNAKMT2A | |
| SCHEMBL13097801 | 0.86 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2MAPK10LMNAKMT2A | |
| SCHEMBL13097792 | 0.84 | KMT2A (0.51) | ALDH1A1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL13097723 | 0.82 | CYP2D6 (0.43) | ALDH1A1SMN1; SMN2MAPK10LMNAKMT2A | |
| SCHEMBL13097549 | 0.81 | L3MBTL1 (0.60) | ALDH1A1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL13097727 | 0.80 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2MAPK10LMNAKMT2A | |
| SCHEMBL13097800 | 0.80 | CYP2D6 (0.51) | ALDH1A1SMN1; SMN2MAPK10LMNAKMT2A | |
| SCHEMBL13097804 | 0.78 | CYP2D6 (0.54) | ALDH1A1SMN1; SMN2MAPK10LMNAKMT2A | |
| SCHEMBL13097904 | 0.78 | SMN1; SMN2 (0.45) | ALDH1A1SMN1; SMN2MAPK10LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367702-B2 | Quinolone derivative | ASTELLAS PHARMA INC. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-8367702-B2 | Quinolone derivative | ASTELLAS PHARMA INC. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-20100256113-A1 | QUINOLONE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2010-10-07 | — | — | US | disclosed |
| US-20100256113-A1 | QUINOLONE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2010-10-07 | — | — | US | disclosed |
| EP-2194044-A1 | QUINOLONE DERIVATIVE | Astellas Pharma Inc. (JP) | 2010-06-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256113-A1 | QUINOLONE DERIVATIVE | NQO1, NQO2, NADK | ALDH1A1 524/4885SMN1; SMN2 4848/4885MAPK10 2359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.