Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.53 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.46 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.45 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.45 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1950805 | 0.86 | TP53BP1 (0.51) | TP53BP1ALDH1A1KMT2AMAP4K1PLOD2 | |
| SCHEMBL3319386 | 0.80 | ALDH1A1 (0.73) | CHEK1KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL29631156 | 0.80 | ALDH1A1 (0.73) | CHEK1KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL1581704 | 0.79 | JAK2 (0.48) | MAP4K1HTR3A | |
| SCHEMBL30735978 | 0.78 | ACACB (0.48) | CHEK1TP53BP1KDM4EALDH1A1 | |
| SCHEMBL12547524 | 0.76 | AOC3 (0.46) | MAP4K1HRH4HTR3A | |
| SCHEMBL2384246 | 0.76 | CHEK1 (0.59) | CHEK1TP53BP1MAP4K1PLOD2PLOD3 | |
| SCHEMBL27868880 | 0.76 | CHEK1 (0.52) | CHEK1KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL998233 | 0.75 | PRKD1 (0.74) | CHEK1MAP4K1PRKD1 | |
| SCHEMBL4873418 | 0.75 | NPC1 (0.56) | CHEK1ALDH1A1NPC1RAB9APRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557813-B2 | 2-benzylpyridazinone derivatives as met kinase inhibitors | MERCK PATENT GMBH (DE) | 2013-10-15 | — | — | US | disclosed |
| US-8557813-B2 | 2-benzylpyridazinone derivatives as met kinase inhibitors | MERCK PATENT GMBH (DE) | 2013-10-15 | — | — | US | disclosed |
| US-20100273796-A1 | 2-BENZYLPYRIDAZINONE DERIVATIVES AS MET KINASE INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-10-28 | — | — | US | disclosed |
| US-20100273796-A1 | 2-BENZYLPYRIDAZINONE DERIVATIVES AS MET KINASE INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273796-A1 | 2-BENZYLPYRIDAZINONE DERIVATIVES AS MET KINASE INHIBITORS | ERBB2, RET, MET | CHEK1 255/4885TP53BP1 856/4885KDM4E 231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.