SCHEMBL13101136

SCHEMBL13101136

CC(=O)NC[C@H]1CN(c2cc(F)c(N3CCn4c(=O)c5ccc(Cl)nc5n4CC3)c(F)c2)C(=O)O1

nearest known ligand 0.51

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOA P21397 5/20 0.51
MAOB P27338 2/20 0.51
PTGS1 P23219 2/20 0.51
SDHA P31040 2/20 0.51
LMNA P02545 1/20 0.51
CALML3 P27482 1/20 0.51
F10 P00742 4/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13101137 0.89 MAOA (0.49) MAOAMAOBPTGS1SDHALMNA
SCHEMBL13101140 0.89 MAOA (0.49) MAOAMAOBPTGS1SDHALMNA
SCHEMBL10152852 0.88 MAOA (0.49) MAOAMAOBPTGS1SDHALMNA
SCHEMBL10152843 0.86 MAOA (0.49) MAOAMAOBPTGS1SDHALMNA
SCHEMBL10151605 0.86 MAOA (0.51) MAOAMAOBPTGS1SDHALMNA
SCHEMBL13101170 0.85 MAOA (0.45) MAOAMAOBPTGS1SDHALMNA
SCHEMBL10152848 0.83 MAOA (0.49) MAOAMAOBPTGS1SDHALMNA
SCHEMBL10152846 0.82 MAOA (0.49) MAOAMAOBPTGS1SDHALMNA
SCHEMBL10151951 0.82 MAOA (0.51) MAOAMAOBPTGS1SDHALMNA
SCHEMBL10151969 0.82 MAOA (0.51) MAOAMAOBPTGS1SDHALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8530646-B2 Oxazolidinone derivative having 7-membered hetero ring RESEARCH FOUNDATION ITSUU LABORATORY (JP) 2013-09-10 US disclosed
US-8530646-B2 Oxazolidinone derivative having 7-membered hetero ring RESEARCH FOUNDATION ITSUU LABORATORY (JP) 2013-09-10 US disclosed
US-20100256355-A1 OXAZOLIDINONE DERIVATIVE HAVING 7-MEMBERED HETERO RING Research Foundation ITSUU Laboratory and Shionogi & Co., Ltd. 2010-10-07 US disclosed
US-20100256355-A1 OXAZOLIDINONE DERIVATIVE HAVING 7-MEMBERED HETERO RING Research Foundation ITSUU Laboratory and Shionogi & Co., Ltd. 2010-10-07 US disclosed
EP-2233484-A2 Oxazolidinone derivatives having a 7-membered heterocyclic ring Research Foundation Itsuu Laboratory (JP) 2010-09-29 EP disclosed
EP-2208729-A1 OXAZOLIDINONE DERIVATIVE HAVING 7-MEMBERED HETERO RING Research Foundation Itsuu Laboratory (JP) 2010-07-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100256355-A1 OXAZOLIDINONE DERIVATIVE HAVING 7-MEMBERED HETERO RING NR0B2, NR0B1, NR2C2 MAOA 2966/4885MAOB 2570/4885PTGS1 4086/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.