Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.42 |
| ▸ | HCAR1 | Q9BXC0 | 7/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.37 |
| ▸ | F11 | P03951 | 1/20 | 0.37 |
| ▸ | TXN | P10599 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535528 | 0.76 | CA12 (0.48) | KDM4EPDE3BPDE3AHCAR1CA12 | |
| SCHEMBL11465933 | 0.74 | PDE3B (0.41) | PDE3BPDE3AHCAR1CA12CA9 | |
| SCHEMBL17442949 | 0.72 | F11 (0.48) | KDM4EPDE3BPDE3AHCAR1CA12 | |
| SCHEMBL25911486 | 0.72 | CA12 (0.41) | KDM4EPDE3BPDE3AHCAR1CA12 | |
| SCHEMBL12044912 | 0.72 | PDE10A (0.37) | KDM4EDDAH1PDE10A | |
| SCHEMBL19233139 | 0.72 | CA12 (0.41) | KDM4EPDE3BPDE3AHCAR1CA12 | |
| SCHEMBL29547698 | 0.72 | CA12 (0.41) | KDM4EPDE3BPDE3AHCAR1CA12 | |
| SCHEMBL26920936 | 0.72 | PDE3B (0.42) | PDE3BPDE3AHCAR1CA12CA9 | |
| SCHEMBL30564985 | 0.71 | SIRT2 (0.45) | KDM4EPDE3BPDE3AHCAR1CA12 | |
| SCHEMBL13094338 | 0.71 | CA12 (0.44) | KDM4EPDE3BPDE3AHCAR1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100266714-A1 | P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | MERCK SHARP & DOHME LLC | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100266714-A1 | P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | P2RX3, P2RX1, P2RX2 | KDM4E 4010/4885PDE3B 756/4885PDE3A 591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.