Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.69 |
| ▸ | TAF1 | P21675 | 2/20 | 0.69 |
| ▸ | PLK1 | P53350 | 15/20 | 0.61 |
| ▸ | PLK3 | Q9H4B4 | 8/20 | 0.61 |
| ▸ | PLK2 | Q9NYY3 | 8/20 | 0.61 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.61 |
| ▸ | BRDT | Q58F21 | 6/20 | 0.57 |
| ▸ | STK4 | Q13043 | 1/20 | 0.55 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.53 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25785687 | 0.86 | PLK1 (0.80) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL13104998 | 0.83 | BRD4 (0.72) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL4108282 | 0.78 | PLK1 (0.61) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL27369587 | 0.77 | PLK1 (0.78) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL27369585 | 0.77 | PLK1 (0.75) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL25118888 | 0.77 | STK4 (0.79) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL2396059 | 0.77 | PLK1 (0.59) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL375880 | 0.77 | PLK1 (0.77) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL376015 | 0.77 | PLK1 (0.77) | BRD4TAF1PLK1PLK3PLK2 | |
| SCHEMBL21527106 | 0.76 | PLK1 (0.70) | BRD4TAF1PLK1PLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7807831-B2 | Dihydropteridione derivatives, process for their manufacture and their use as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-10-05 | — | — | US | disclosed |
| US-7807831-B2 | Dihydropteridione derivatives, process for their manufacture and their use as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-10-05 | — | — | US | disclosed |
| US-7723517-B2 | Dihydropteridione derivatives, process for their manufacture and their use as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH | 2010-05-25 | — | — | US | disclosed |
| US-7723517-B2 | Dihydropteridione derivatives, process for their manufacture and their use as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH | 2010-05-25 | — | — | US | disclosed |
| US-7700769-B2 | Dihydropteridione derivatives, process for their manufacture and their use as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-20 | — | — | US | disclosed |
| US-7700769-B2 | Dihydropteridione derivatives, process for their manufacture and their use as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-20 | — | — | US | disclosed |
| US-7629460-B2 | Dihydropteridione derivatives, process for their manufacture and their use as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-08 | — | — | US | disclosed |
| US-7629460-B2 | Dihydropteridione derivatives, process for their manufacture and their use as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-08 | — | — | US | disclosed |
| US-20090018333-A1 | Dihydropteridione derivatives, process for their manufacture and their use as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-01-15 | — | — | US | disclosed |
| US-20090018333-A1 | Dihydropteridione derivatives, process for their manufacture and their use as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-01-15 | — | — | US | disclosed |
| US-20080319193-A1 | New dihydropteridione derivatives, process for their manufacture and their use as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-25 | — | — | US | disclosed |
| US-20080319193-A1 | New dihydropteridione derivatives, process for their manufacture and their use as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-25 | — | — | US | disclosed |
| US-20080319192-A1 | New dihydropteridione derivatives, process for their manufacture and their use as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-25 | — | — | US | disclosed |
| US-20080319192-A1 | New dihydropteridione derivatives, process for their manufacture and their use as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-25 | — | — | US | disclosed |
| US-20080319190-A1 | Antitumor agents; antiproliferative agents | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-25 | — | — | US | disclosed |
| US-20080319190-A1 | Antitumor agents; antiproliferative agents | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-25 | — | — | US | disclosed |
| US-7414053-B2 | Dihydropteridione derivatives, process for their manufacture and their use as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-19 | — | — | US | disclosed |
| US-7414053-B2 | Dihydropteridione derivatives, process for their manufacture and their use as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319192-A1 | New dihydropteridione derivatives, process for their manufacture and their use as medicament | QDPR, DHPS, DHCR7 | BRD4 4130/4885TAF1 4854/4885PLK1 4192/4885 |
| US-20080319193-A1 | New dihydropteridione derivatives, process for their manufacture and their use as medicament | QDPR, DHPS, DHCR7 | BRD4 4130/4885TAF1 4854/4885PLK1 4192/4885 |
| US-20090018333-A1 | Dihydropteridione derivatives, process for their manufacture and their use as medicament | QDPR, DHPS, DHODH | BRD4 4409/4885TAF1 4858/4885PLK1 4325/4885 |
| US-20080319190-A1 | Antitumor agents; antiproliferative agents | TPD52L2, MKI67, HCCS | BRD4 3570/4885TAF1 4708/4885PLK1 1218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.