Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 9/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | IL18 | Q14116 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16099226 | 0.85 | HPGD (0.50) | TP53TSHRLMNAKMT2AMEN1 | |
| SCHEMBL8129896 | 0.80 | ALDH1A1 (0.51) | TP53TSHRKMT2AMAPK1KDM4E | |
| SCHEMBL12329455 | 0.77 | RAF1 (0.43) | RAF1TP53LMNAKMT2AMAPK1 | |
| SCHEMBL8115817 | 0.77 | TP53 (0.67) | TP53TSHRLMNAKMT2AMEN1 | |
| SCHEMBL13106903 | 0.76 | RAF1 (0.42) | RAF1TP53LMNAKMT2AMAPK1 | |
| SCHEMBL8128211 | 0.75 | ALDH1A1 (0.47) | TP53TSHRLMNAKMT2AMAPK1 | |
| SCHEMBL4680211 | 0.74 | LMNA (0.66) | LMNAKMT2AMAPK1KDM4EMEN1 | |
| SCHEMBL10453690 | 0.73 | LMNA (0.49) | TP53TSHRLMNAKMT2AMAPK1 | |
| SCHEMBL8126525 | 0.73 | LMNA (0.43) | TP53TSHRLMNAKMT2AMEN1 | |
| SCHEMBL8126275 | 0.73 | HTT (0.61) | TP53TSHRLMNAKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816365-B2 | Amine derivatives | MERCK PATENT GMBH (DE) | 2010-10-19 | — | — | US | disclosed |
| US-7816365-B2 | Amine derivatives | MERCK PATENT GMBH (DE) | 2010-10-19 | — | — | US | disclosed |
| US-20070112006-A1 | Amine derivatives | MERCK PATENT GMBH (DE) | 2007-05-17 | — | — | US | disclosed |
| US-20070112006-A1 | Amine derivatives | MERCK PATENT GMBH (DE) | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112006-A1 | Amine derivatives | TIE1, FLT1, KDR | RAF1 23/4885TP53 241/4885TSHR 802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.