Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 4/20 | 0.54 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13115449 | 0.88 | CYP11B2 (0.51) | CYP11B2NPY5RMAPK14MAPK13MAPK12 | |
| SCHEMBL13115328 | 0.88 | CYP11B2 (0.54) | CYP11B2NPY5RMAPK14MAPK13MAPK12 | |
| SCHEMBL13115443 | 0.86 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL13115465 | 0.85 | CYP11B2 (0.50) | CYP11B2NPY5RMAPK14MAPK13MAPK12 | |
| SCHEMBL13115431 | 0.84 | CYP11B1 (0.50) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL13115477 | 0.83 | CYP11B2 (0.48) | CYP11B2NPY5RMAPK14MAPK13MAPK12 | |
| SCHEMBL13115439 | 0.79 | NPC1 (0.48) | CYP11B2NPY5RCYP19A1CYP11B1DHODH | |
| SCHEMBL13115335 | 0.76 | CYP19A1 (0.49) | CYP11B2NPY5RMAPK14CYP19A1CYP11B1 | |
| SCHEMBL13115448 | 0.73 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL13115451 | 0.73 | CYP11B1 (0.47) | NPY5RMAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256165-A1 | LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER | HONGU MITSUYA | 2010-10-07 | — | — | US | disclosed |
| US-7759373-B2 | Large conductance calcium-activated K channel opener | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256165-A1 | LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER | KCNN3, KCNN2, KCNN1 | CYP11B2 4104/4885NPY5R 695/4885MAPK14 1232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.