Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CHKA | P35790 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143939 | 0.84 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2MEN1KMT2AMC4R | |
| SCHEMBL4144775 | 0.84 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2MEN1KMT2AMC4R | |
| SCHEMBL13990823 | 0.83 | KDM4E (0.51) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL30564341 | 0.83 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2MEN1KMT2AMC4R | |
| SCHEMBL14049742 | 0.81 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2MEN1KMT2AMC4R | |
| SCHEMBL13115535 | 0.81 | HTT (0.57) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2283356 | 0.80 | GFER (0.62) | ALDH1A1SMN1; SMN2MEN1KMT2AMC4R | |
| SCHEMBL12794019 | 0.79 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2MEN1KMT2AMC4R | |
| SCHEMBL10211581 | 0.77 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2MEN1KMT2AMC4R | |
| SCHEMBL2282763 | 0.77 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2MEN1KMT2AMC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013020246-A1 | METHYLENE DERIVATIVES OF BETULIN | GLAXOSMITHKLINE LLC (US) | 2013-02-14 | — | — | WO | disclosed |
| US-20100256356-A1 | HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2010-10-07 | — | — | US | disclosed |
| US-7723330-B2 | Heterobicyclic pyrazole compounds and methods of use | ARRAY BIOPHARMA INC. (US) | 2010-05-25 | — | — | US | disclosed |
| US-20070238726-A1 | Heterobicyclic pyrazole compounds and methods of use | GENENTECH, INC. | 2007-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256356-A1 | HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE | ROR1, CYP11B1, CYP11B2 | ALDH1A1 1929/4885SMN1; SMN2 1840/4885MEN1 2329/4885 |
| US-20070238726-A1 | Heterobicyclic pyrazole compounds and methods of use | ROR1, CYP11B1, CYP11B2 | ALDH1A1 1929/4885SMN1; SMN2 1840/4885MEN1 2329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.