Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 13/20 | 0.60 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.60 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.48 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1315000 | 0.94 | SPHK1 (0.62) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL30143661 | 0.91 | SPHK1 (0.67) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL29880747 | 0.87 | SPHK1 (0.56) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL23007751 | 0.86 | SPHK1 (0.54) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL1314104 | 0.85 | PPARA (0.52) | HDAC4HDAC1CTSK | |
| SCHEMBL21049585 | 0.81 | SPHK1 (0.59) | SPHK1SPHK2S1PR1 | |
| SCHEMBL5443688 | 0.81 | SPHK1 (0.51) | SPHK1SPHK2S1PR1S1PR3S1PR2 | |
| SCHEMBL27613652 | 0.81 | HDAC4 (0.61) | HDAC4HDAC1CTSK | |
| SCHEMBL13181089 | 0.80 | HPGD (0.57) | SPHK1S1PR1 | |
| SCHEMBL5454624 | 0.80 | CTSK (0.55) | S1PR1S1PR2CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | SPHK1, SPHK2, S1PR1 | SPHK1 1/4885SPHK2 2/4885S1PR1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.