Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2741012 | 0.81 | CRHBP (0.53) | ALDH1A1SMN1; SMN2LMNAKMT2AKDM4E | |
| SCHEMBL13165623 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAKMT2AKDM4EMEN1 | |
| SCHEMBL13128959 | 0.68 | KDM4E (0.54) | ALDH1A1SMN1; SMN2GRM4LMNAKMT2A | |
| SCHEMBL2740997 | 0.67 | MCL1 (0.62) | SMN1; SMN2PTK2BGRM4KMT2ATSHR | |
| SCHEMBL2741004 | 0.66 | CRHBP (0.51) | ALDH1A1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL2740999 | 0.65 | MAPT (0.49) | ALDH1A1SMN1; SMN2PTK2BLMNAKMT2A | |
| SCHEMBL14160326 | 0.65 | MEN1 (0.46) | ALDH1A1SMN1; SMN2PTK2BLMNAKMT2A | |
| SCHEMBL14161620 | 0.64 | POLB (0.60) | SMN1; SMN2PTK2BKMT2ATSHRKDM4E | |
| SCHEMBL3817707 | 0.63 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2PTK2BGRM4LMNA | |
| SCHEMBL2740996 | 0.62 | PTGES2 (0.56) | SMN1; SMN2PTK2BKMT2ATSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249135-A1 | SULFONAMIDES AND THEIR USE AS A MEDICAMENT | THE GENETICS COMPANY, INC. (CH) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249135-A1 | SULFONAMIDES AND THEIR USE AS A MEDICAMENT | BCOR, CBR3, SULT1E1 | ALDH1A1 3484/4885SMN1; SMN2 2187/4885PTK2B 2888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.