Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 9/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.48 |
| ▸ | HTT | P42858 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 9/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2741004 | 0.85 | CRHBP (0.51) | CRHBPCRHR2KEAP1NFE2L2NHERF1 | |
| SCHEMBL2740989 | 0.82 | MEN1 (0.52) | CRHBPCRHR2KEAP1NFE2L2NHERF1 | |
| SCHEMBL2740998 | 0.82 | CRHBP (0.60) | CRHBPCRHR2NHERF1MEN1KMT2A | |
| SCHEMBL13128981 | 0.81 | ALDH1A1 (0.45) | MEN1KMT2AHTTSMN1; SMN2MAPT | |
| SCHEMBL15647549 | 0.80 | NFKBIA (0.61) | CRHBPCRHR2NHERF1MEN1KMT2A | |
| SCHEMBL2740957 | 0.80 | MEN1 (0.50) | CRHBPCRHR2KEAP1NFE2L2NHERF1 | |
| SCHEMBL2740990 | 0.80 | L3MBTL1 (0.57) | CRHBPCRHR2MEN1KMT2AHTT | |
| SCHEMBL2740994 | 0.79 | L3MBTL1 (0.59) | CRHBPCRHR2KEAP1NFE2L2MEN1 | |
| SCHEMBL2741006 | 0.79 | MEN1 (0.55) | CRHBPCRHR2NHERF1MEN1KMT2A | |
| SCHEMBL2741007 | 0.78 | MEN1 (0.58) | CRHBPCRHR2MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088772-B2 | Sulfonamides and their use as a medicament | THE GENETICS COMPANY, INC. (CH) | 2012-01-03 | — | — | US | disclosed |
| US-8088772-B2 | Sulfonamides and their use as a medicament | THE GENETICS COMPANY, INC. (CH) | 2012-01-03 | — | — | US | disclosed |
| EP-1932830-A1 | Sulfonamides and their use as a medicament | The Genetics Company, Inc. (CH) | 2008-06-18 | — | — | EP | disclosed |