⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7453432 | 1.00 | — | — | |
| SCHEMBL611508 | 0.88 | — | — | |
| SCHEMBL5548835 | 0.88 | — | — | |
| SCHEMBL9793964 | 0.88 | — | — | |
| SCHEMBL9793827 | 0.86 | TP53 (0.41) | — | |
| SCHEMBL9793843 | 0.86 | TP53 (0.41) | — | |
| SCHEMBL13674295 | 0.86 | TP53 (0.41) | — | |
| SCHEMBL612202 | 0.86 | TP53 (0.41) | — | |
| SCHEMBL9063598 | 0.86 | TP53 (0.41) | — | |
| SCHEMBL17889770 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1129567-C | Process for preparation of cyclopropylacetylene derivatives | KURARAY CO (JP) | 2003-12-03 | — | — | CN | claimed |
| CN-1232815-A | Process for preparation of cyclopropylacetylene derivatives | KURARAY CO (JP) | 1999-10-27 | — | — | CN | claimed |
| US-20260042759-A1 | INHIBITOR CONTAINING BICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI HANSOH BIOMEDICAL CO LTD (CN) | 2026-02-12 | — | — | US | disclosed |
| US-12466823-B2 | Inhibitor containing bicyclic derivative, preparation method therefor and use thereof | SHANGHAI HANSOH BIOMEDICAL CO., LTD. (CN) | 2025-11-11 | — | — | US | disclosed |
| EP-3971187-B1 | INHIBITOR CONTAINING BICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI HANSOH BIOMEDICAL CO LTD (CN) | 2025-05-07 | — | — | EP | disclosed |
| CN-117800904-A | ROR gamma inhibitors containing sulfonyl structures | 正大天晴药业集团股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| US-20230406865-A1 | CRYSTAL FORM OF FREE BASE OF INHIBITOR CONTAINING BICYCLIC RING DERIVATIVE AND PREPARATION METHOD AND APPLICATION OF CRYSTAL FORM | JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) | 2023-12-21 | — | — | US | disclosed |
| CN-113166061-B | ROR gamma inhibitors containing sulfonyl structures | 正大天晴药业集团股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| EP-4245757-A1 | CRYSTAL FORM OF FREE BASE OF INHIBITOR CONTAINING BICYCLIC RING DERIVATIVE AND PREPARATION METHOD AND APPLICATION OF CRYSTAL FORM | Shanghai Hansoh Biomedical Co., Ltd. (CN) | 2023-09-20 | — | — | EP | disclosed |
| CN-116528859-A | Crystal form containing free alkali of di-fused ring derivative inhibitor and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-08-01 | — | — | CN | disclosed |
| CN-116444515-A | Di-ring derivative-containing inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-07-18 | — | — | CN | disclosed |
| EP-0866791-B1 | DIAMINOPYRIMIDINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIBACTERIAL | ARPIDA AG (CH) | 2002-01-30 | — | — | EP | disclosed |
| EP-1149834-A1 | Diaminopyrimidines, pharmaceutical compositions containing them and their use as antibacterial | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-6143743-A | TREATMENT OF NERVOUS SYSTEM DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-11-07 | — | — | US | disclosed |
| EP-0994877-A1 | IMIDAZOPYRIMIDINES AND IMIDAZOPYRIDINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | Du Pont Pharmaceuticals Company (US) | 2000-04-26 | — | — | EP | disclosed |
| CN-1232815-A | Process for preparation of cyclopropylacetylene derivatives | KURARAY CO (JP) | 1999-10-27 | — | — | CN | disclosed |
| WO-1999001454-A1 | IMIDAZOPYRIMIDINES AND IMIDAZOPYRIDINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-01-14 | — | — | WO | disclosed |
| EP-0866791-A1 | DIAMINOPYRIMIDINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIBACTERIAL | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-30 | — | — | EP | disclosed |
| US-5773446-A | BACTERICIDES; CONTROLLING INFECTIONS | HOFFMANN-LA ROCHE INC. (US) | 1998-06-30 | — | — | US | disclosed |
| WO-1997020839-A1 | DIAMINOPYRIMIDINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIBACTERIAL | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-12 | — | — | WO | disclosed |