⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9793964 | 1.00 | — | — | |
| SCHEMBL9063598 | 0.97 | TP53 (0.41) | — | |
| SCHEMBL9793843 | 0.97 | TP53 (0.41) | — | |
| SCHEMBL9793827 | 0.97 | TP53 (0.41) | — | |
| SCHEMBL612202 | 0.97 | TP53 (0.41) | — | |
| SCHEMBL13674295 | 0.97 | TP53 (0.41) | — | |
| SCHEMBL5548835 | 0.94 | — | — | |
| SCHEMBL7453432 | 0.88 | — | — | |
| SCHEMBL131334 | 0.88 | — | — | |
| SCHEMBL17889770 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115364903-B | Preparation method of catalyst for synthesizing alpha-hydroxyketone | 东南大学 | 2024-03-12 | — | — | CN | claimed |
| CN-115364903-A | Preparation method of catalyst for synthesizing alpha-hydroxyketone | 东南大学 | 2022-11-22 | — | — | CN | claimed |
| CN-115364903-B | Preparation method of catalyst for synthesizing alpha-hydroxyketone | 东南大学 | 2024-03-12 | — | — | CN | disclosed |
| CN-115364903-A | Preparation method of catalyst for synthesizing alpha-hydroxyketone | 东南大学 | 2022-11-22 | — | — | CN | disclosed |
| US-8557828-B2 | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBVIE INC. (US) | 2013-10-15 | — | — | US | disclosed |
| US-8470847-B2 | Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics | SANOFI (FR) | 2013-06-25 | — | — | US | disclosed |
| EP-2500347-A1 | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | Abbott Laboratories (US) | 2012-09-19 | — | — | EP | disclosed |
| EP-2142552-B1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LAB (US) | 2012-08-01 | — | — | EP | disclosed |
| US-20120041003-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | US | disclosed |
| US-8076344-B2 | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBOTT LABORATORIES (US) | 2011-12-13 | — | — | US | disclosed |
| EP-2158201-B1 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2011-04-13 | — | — | EP | disclosed |
| EP-0255098-B1 | Novel 8-(lower alkyl) bicyclo [4.2.0] octane derivatives with valuable therapeutic properties | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4983627-A | Treating atherosclerosis, thrombosis and vasospasms; anticholesterol,-secretory,-ulcer and hypotensive agents | SYNTEX (U.S.A.) INC. (US) | 1991-01-08 | — | — | US | disclosed |
| EP-0196617-B1 | [4.2.0]bicyclooctane derivatives, process for their preparation and pharmaceutical compositions containing same | SYNTEX (U.S.A.) INC. (US) | 1989-05-31 | — | — | EP | disclosed |
| US-4735966-A | ANTICOAGULANTS, VASODILATORS, HYPOTENSIVE AND ANTICHOLESTEROL AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-04-05 | — | — | US | disclosed |
| EP-0257609-A2 | Novel substituted (4.2.0)Bicyclooctane derivatives with valuable therapeutic properties | SYNTEX (U.S.A.) INC. (US) | 1988-03-02 | — | — | EP | disclosed |
| EP-0255098-A1 | Novel 8-(lower alkyl) bicyclo [4.2.0] octane derivatives with valuable therapeutic properties | SYNTEX (U.S.A.) INC. (US) | 1988-02-03 | — | — | EP | disclosed |
| US-4678805-A | Novel 8-(lower alkyl)bicyclo[4.2.0]octane derivatives with valuable therapeutic properties | SYNTEX (U.S.A.) INC. (US) | 1987-07-07 | — | — | US | disclosed |
| EP-0196617-A1 | [4.2.0]bicyclooctane derivatives, process for their preparation and pharmaceutical compositions containing same | SYNTEX (U.S.A.) INC. (US) | 1986-10-08 | — | — | EP | disclosed |
| US-4608388-A | Novel [4,2,0]bicyclooctane derivatives with valuable therapeutic properties | SYNTEX (U.S.A.) INC. (US) | 1986-08-26 | — | — | US | disclosed |