Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 9/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.43 |
| ▸ | TESK1 | Q15569 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2865910 | 0.86 | KARS1 (0.58) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL2865766 | 0.85 | KDR (0.59) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL2866163 | 0.85 | KARS1 (0.54) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL2862806 | 0.84 | KDR (0.57) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL2863826 | 0.83 | MEN1 (0.57) | KARS1MEN1NPC1KMT2AMAPT | |
| SCHEMBL14390976 | 0.83 | KDR (0.56) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL2859100 | 0.82 | KARS1 (0.52) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL13136179 | 0.82 | SYK (0.53) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL13136251 | 0.82 | KARS1 (0.60) | KARS1KDRSYKMEN1NPC1 | |
| SCHEMBL13136090 | 0.82 | KARS1 (0.56) | KARS1KDRSYKJAK2LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| EP-1854793-A1 | NOVEL AMINOPYRIDINE COMPOUND WITH Syk INHIBITORY ACTIVITY | Japan Tobacco, Inc. (JP) | 2007-11-14 | — | — | EP | disclosed |