Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.44 |
| ▸ | KARS1 | Q15046 | 8/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136175 | 0.91 | KARS1 (0.44) | SYKKARS1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL13136123 | 0.91 | SYK (0.46) | SYKKARS1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL13136039 | 0.91 | SYK (0.49) | SYKKARS1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL13136095 | 0.91 | SYK (0.44) | SYKKARS1ACACB | |
| SCHEMBL13136176 | 0.91 | SYK (0.43) | SYKKARS1SMN1; SMN2ALDH1A1ACACB | |
| SCHEMBL13136211 | 0.89 | NPC1 (0.49) | SYKKARS1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL13136056 | 0.85 | SYK (0.49) | SYKKARS1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL13136171 | 0.85 | KARS1 (0.47) | SYKKARS1SMN1; SMN2ALDH1A1MAPK10 | |
| SCHEMBL13136213 | 0.84 | SYK (0.41) | SYKKARS1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL13136042 | 0.83 | SYK (0.46) | SYKKARS1SMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |