Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 11/20 | 0.47 |
| ▸ | SYK | P43405 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136210 | 0.90 | KARS1 (0.52) | KARS1SYKSMN1; SMN2KDRKDM4E | |
| SCHEMBL13136033 | 0.90 | KARS1 (0.53) | KARS1SYKALDH1A1KDRKDM4E | |
| SCHEMBL13136094 | 0.90 | KARS1 (0.46) | KARS1SYKALDH1A1KDRKDM4E | |
| SCHEMBL13136174 | 0.90 | KARS1 (0.46) | KARS1SYKKDR | |
| SCHEMBL13136375 | 0.89 | KARS1 (0.48) | KARS1SYKKDR | |
| SCHEMBL13136172 | 0.85 | SYK (0.44) | KARS1SYKALDH1A1MAPK10SMN1; SMN2 | |
| SCHEMBL2865508 | 0.83 | KARS1 (0.52) | KARS1SYKKDR | |
| SCHEMBL2865504 | 0.83 | KARS1 (0.52) | KARS1SYKKDR | |
| SCHEMBL13136173 | 0.83 | KARS1 (0.48) | KARS1SYKALDH1A1MAPK10SMN1; SMN2 | |
| SCHEMBL2225653 | 0.82 | KARS1 (0.53) | KARS1SYKSMN1; SMN2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |