Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 11/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136171 | 0.90 | KARS1 (0.47) | KARS1SYKKDR | |
| SCHEMBL13136210 | 0.87 | KARS1 (0.52) | KARS1MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL13136033 | 0.86 | KARS1 (0.53) | KARS1MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL13136375 | 0.86 | KARS1 (0.48) | KARS1MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL13136176 | 0.85 | SYK (0.43) | KARS1MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL13136094 | 0.83 | KARS1 (0.46) | KARS1MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL2865508 | 0.81 | KARS1 (0.52) | KARS1MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL2865504 | 0.81 | KARS1 (0.52) | KARS1MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL13136041 | 0.80 | KARS1 (0.50) | KARS1MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL2862731 | 0.79 | KARS1 (0.55) | KARS1MEN1RAB9AKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |