Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | KARS1 | Q15046 | 6/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 4/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136095 | 0.89 | SYK (0.44) | P4HBSYKKARS1ACACBPPARD | |
| SCHEMBL2866182 | 0.88 | SYK (0.48) | SYKKARS1KDRJAK2MEN1 | |
| SCHEMBL2866177 | 0.88 | SYK (0.48) | SYKKARS1KDRJAK2MEN1 | |
| SCHEMBL13136185 | 0.86 | KARS1 (0.47) | P4HBSYKKARS1SLC2A1KDR | |
| SCHEMBL13136042 | 0.85 | SYK (0.46) | SYKKARS1KDRJAK2MEN1 | |
| SCHEMBL13136087 | 0.83 | ACACB (0.44) | SYKACACBACACAKDRPPARD | |
| SCHEMBL13136039 | 0.83 | SYK (0.49) | SYKKARS1KDRJAK2MEN1 | |
| SCHEMBL13136094 | 0.82 | KARS1 (0.46) | P4HBSYKKARS1SLC2A1KDR | |
| SCHEMBL13136092 | 0.82 | PTPRB (0.50) | SYKKARS1JAK2KMT2A | |
| SCHEMBL13136120 | 0.81 | SYK (0.44) | SYKKARS1KDRJAK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |