Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 11/20 | 0.47 |
| ▸ | P4HB | P07237 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136094 | 0.89 | KARS1 (0.46) | KARS1P4HBSYKKDRSLC2A1 | |
| SCHEMBL13136189 | 0.86 | P4HB (0.46) | KARS1P4HBSYKKDRSLC2A1 | |
| SCHEMBL13136041 | 0.84 | KARS1 (0.50) | KARS1SYKKDRMEN1NPC1 | |
| SCHEMBL13136169 | 0.83 | KARS1 (0.47) | KARS1P4HBSYKKDRSLC2A1 | |
| SCHEMBL13136033 | 0.82 | KARS1 (0.53) | KARS1SYKKDRSLC2A1MEN1 | |
| SCHEMBL13136095 | 0.82 | SYK (0.44) | KARS1P4HBSYK | |
| SCHEMBL13136422 | 0.81 | KARS1 (0.44) | KARS1P4HBSYKKDRSLC2A1 | |
| SCHEMBL13136092 | 0.79 | PTPRB (0.50) | KARS1SYKKMT2AJAK2 | |
| SCHEMBL13136115 | 0.79 | SYK (0.45) | KARS1SYKKDRNPC1RAB9A | |
| SCHEMBL2862731 | 0.79 | KARS1 (0.55) | KARS1SYKKDRSLC2A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| EP-1854793-A1 | NOVEL AMINOPYRIDINE COMPOUND WITH Syk INHIBITORY ACTIVITY | Japan Tobacco, Inc. (JP) | 2007-11-14 | — | — | EP | disclosed |