SCHEMBL13136201

SCHEMBL13136201

Cc1ccnc(Nc2cccc(-c3cnc(CN4CCC(C(=O)O)CC4)s3)n2)c1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SYK P43405 18/20 0.56
KARS1 Q15046 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2870296 0.92 SYK (0.51) SYKKARS1
SCHEMBL13136506 0.92 SYK (0.51) SYKKARS1
SCHEMBL13136206 0.90 SYK (0.52) SYKKARS1
SCHEMBL2862515 0.89 SYK (0.51) SYKKARS1
SCHEMBL13136654 0.89 SYK (0.51) SYKKARS1
SCHEMBL13136236 0.88 SYK (0.51) SYKKARS1
SCHEMBL2869599 0.88 KARS1 (0.58) SYKKARS1
SCHEMBL13136222 0.87 KDR (0.53) SYKKARS1
SCHEMBL13136264 0.87 SYK (0.49) SYKKARS1
SCHEMBL2859023 0.86 SYK (0.57) SYKKARS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7803801-B2 Aminopyridine compounds having Syk inhibitory activity JAPAN TOBACCO, INC. (JP) 2010-09-28 US disclosed
US-7803801-B2 Aminopyridine compounds having Syk inhibitory activity JAPAN TOBACCO, INC. (JP) 2010-09-28 US disclosed