Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | SYK | P43405 | 3/20 | 0.51 |
| ▸ | KARS1 | Q15046 | 9/20 | 0.46 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136262 | 0.91 | SYK (0.49) | KDRSYKKARS1MAP3K12 | |
| SCHEMBL13136234 | 0.88 | SYK (0.48) | KDRSYKKARS1MAP3K12 | |
| SCHEMBL13136323 | 0.88 | SYK (0.53) | KDRSYKKARS1MAP3K12 | |
| SCHEMBL13136242 | 0.88 | KARS1 (0.51) | KDRSYKKARS1 | |
| SCHEMBL13136236 | 0.87 | SYK (0.51) | SYKKARS1 | |
| SCHEMBL13136201 | 0.87 | SYK (0.56) | SYKKARS1 | |
| SCHEMBL2862515 | 0.86 | SYK (0.51) | KDRSYKKARS1MAP3K12 | |
| SCHEMBL2870296 | 0.86 | SYK (0.51) | SYKKARS1 | |
| SCHEMBL13136227 | 0.86 | KDR (0.53) | KDRSYKKARS1CHEK1 | |
| SCHEMBL13136224 | 0.85 | SYK (0.47) | KDRSYKKARS1MAP3K12CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |