Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | KARS1 | Q15046 | 7/20 | 0.42 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BLK | P51451 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136213 | 0.89 | SYK (0.41) | SYKKDRAURKAFLT3KARS1 | |
| SCHEMBL13136033 | 0.87 | KARS1 (0.53) | SYKKDRKARS1JAK2MEN1 | |
| SCHEMBL13136375 | 0.84 | KARS1 (0.48) | SYKKDRKARS1POLBJAK2 | |
| SCHEMBL13136041 | 0.82 | KARS1 (0.50) | SYKKDRKARS1JAK2MEN1 | |
| SCHEMBL13136210 | 0.82 | KARS1 (0.52) | SYKKDRKARS1POLBMEN1 | |
| SCHEMBL2865508 | 0.79 | KARS1 (0.52) | SYKKDRKARS1JAK2MEN1 | |
| SCHEMBL13136174 | 0.78 | KARS1 (0.46) | SYKKDRKARS1MEN1KMT2A | |
| SCHEMBL13136211 | 0.78 | NPC1 (0.49) | SYKKDRKARS1MEN1KMT2A | |
| SCHEMBL13136134 | 0.78 | SYK (0.51) | SYKKDRKARS1JAK2 | |
| SCHEMBL13136039 | 0.77 | SYK (0.49) | SYKKDRKARS1JAK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |