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SCHEMBL13136372

SCHEMBL13136372

Cc1ccnc(Nc2cccc(-c3cnc(CNC4CCN(C(=O)OC(C)(C)C)CC4)s3)n2)c1

nearest known ligand 0.52

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 12/20 0.52
▸ CCNT1 O60563 1/20 0.46
▸ NOS3 P29474 1/20 0.45
▸ NOS1 P29475 1/20 0.45
▸ NOS2 P35228 1/20 0.45
▸ KARS1 Q15046 4/20 0.42
▸ LMNA P02545 1/20 0.41
▸ MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13136098 0.86 SYK (0.51) SYKKARS1LMNA
SCHEMBL13136389 0.83 SYK (0.48) SYKKARS1
SCHEMBL13136223 0.82 SYK (0.51) SYKKARS1
SCHEMBL13136244 0.80 SYK (0.51) SYKKARS1
SCHEMBL13136323 0.78 SYK (0.53) SYKKARS1
SCHEMBL13136274 0.78 SYK (0.51) SYKKARS1
SCHEMBL2870010 0.78 SYK (0.49) SYKKARS1
SCHEMBL13136207 0.78 SYK (0.52) SYKNOS3NOS1NOS2KARS1
SCHEMBL13136250 0.78 SYK (0.52) SYKKARS1
SCHEMBL13136332 0.77 SYK (0.48) SYKNOS3NOS1NOS2KARS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7803801-B2 Aminopyridine compounds having Syk inhibitory activity JAPAN TOBACCO, INC. (JP) 2010-09-28 — — US disclosed
US-7803801-B2 Aminopyridine compounds having Syk inhibitory activity JAPAN TOBACCO, INC. (JP) 2010-09-28 — — US disclosed