Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.48 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | KARS1 | Q15046 | 10/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136224 | 0.83 | SYK (0.47) | SYKKARS1 | |
| SCHEMBL13136287 | 0.80 | SYK (0.49) | SYKKARS1 | |
| SCHEMBL13136418 | 0.80 | SYK (0.49) | SYKKARS1 | |
| SCHEMBL13136602 | 0.79 | RAB9A (0.49) | SYKKARS1 | |
| SCHEMBL2869572 | 0.79 | SYK (0.53) | SYKKARS1 | |
| SCHEMBL13136356 | 0.79 | SYK (0.49) | SYKKARS1 | |
| SCHEMBL13136412 | 0.78 | NOS2 (0.50) | SYKNOS3NOS1NOS2KARS1 | |
| Hydrochloric Acid SCHEMBL2868657 | 0.78 | SYK (0.53) | SYKKARS1 | |
| SCHEMBL13136348 | 0.78 | SYK (0.51) | SYKKARS1 | |
| SCHEMBL13136341 | 0.78 | SYK (0.51) | SYKKARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |