Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.64 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2860076 | 0.89 | KARS1 (0.50) | KARS1SYK | |
| SCHEMBL13136401 | 0.89 | KARS1 (0.50) | KARS1SYK | |
| SCHEMBL2860446 | 0.88 | KARS1 (0.49) | KARS1SYKCHEK1 | |
| SCHEMBL13136530 | 0.88 | KARS1 (0.52) | KARS1SYK | |
| SCHEMBL2861431 | 0.86 | KARS1 (0.55) | KARS1SYK | |
| SCHEMBL13136527 | 0.86 | KARS1 (0.51) | KARS1SYKMAP3K12 | |
| SCHEMBL13136395 | 0.85 | KARS1 (0.49) | KARS1SYK | |
| SCHEMBL2868255 | 0.85 | KARS1 (0.48) | KARS1SYKCHEK1 | |
| SCHEMBL13136398 | 0.85 | KARS1 (0.48) | KARS1SYKCHEK1 | |
| SCHEMBL2864564 | 0.85 | SYK (0.51) | KARS1SYKCHEK1MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| EP-1854793-A1 | NOVEL AMINOPYRIDINE COMPOUND WITH Syk INHIBITORY ACTIVITY | Japan Tobacco, Inc. (JP) | 2007-11-14 | — | — | EP | disclosed |