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Sugi Predict / Compounds / SCHEMBL13136398

SCHEMBL13136398

SCHEMBL13136398

Cc1ccnc(Nc2cccc(-c3cnc(N4CCN(S(C)(=O)=O)CC4)s3)n2)c1

nearest known ligand 0.48

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ KARS1 Q15046 12/20 0.48
▸ CHEK1 O14757 2/20 0.47
▸ SYK P43405 2/20 0.47
▸ KDR P35968 2/20 0.45
▸ NPC1 O15118 1/20 0.41
▸ TSHR P16473 1/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ NPSR1 Q6W5P4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2868255 0.93 KARS1 (0.48) KARS1CHEK1SYKKDRRAB9A
SCHEMBL2860076 0.88 KARS1 (0.50) KARS1SYKKDR
SCHEMBL13136395 0.86 KARS1 (0.49) KARS1SYKKDRNPC1RAB9A
SCHEMBL2861295 0.86 KARS1 (0.49) KARS1SYK
SCHEMBL13136401 0.85 KARS1 (0.50) KARS1SYKKDRNPC1RAB9A
SCHEMBL2864564 0.85 SYK (0.51) KARS1CHEK1SYKKDR
SCHEMBL13136227 0.85 KDR (0.53) KARS1CHEK1SYKKDR
SCHEMBL5570313 0.85 SYK (0.49) KARS1SYKKDR
SCHEMBL2860446 0.85 KARS1 (0.49) KARS1CHEK1SYKKDR
SCHEMBL13136392 0.85 KARS1 (0.64) KARS1CHEK1SYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7803801-B2 Aminopyridine compounds having Syk inhibitory activity JAPAN TOBACCO, INC. (JP) 2010-09-28 — — US disclosed
US-7803801-B2 Aminopyridine compounds having Syk inhibitory activity JAPAN TOBACCO, INC. (JP) 2010-09-28 — — US disclosed
EP-1854793-A1 NOVEL AMINOPYRIDINE COMPOUND WITH Syk INHIBITORY ACTIVITY Japan Tobacco, Inc. (JP) 2007-11-14 — — EP disclosed