Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.65 |
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | PPARA | Q07869 | 1/20 | 0.55 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312572 | 0.99 | NPC1 (0.68) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL1312565 | 0.99 | NPC1 (0.68) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL1314368 | 0.85 | CA12 (0.49) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL3133411 | 0.82 | NPC1 (0.68) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL14061846 | 0.80 | NPC1 (0.97) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL24326606 | 0.79 | RAB9A (1.00) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL6468865 | 0.79 | RAB9A (0.60) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL31375520 | 0.79 | RAB9A (0.60) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL16945678 | 0.79 | SPHK2 (0.69) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL16945676 | 0.79 | SPHK2 (0.69) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION | 2011-11-10 | — | — | US | disclosed |
| WO-2010033701-A2 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | SPHK1, SPHK2, S1PR1 | NPC1 137/4885RAB9A 3029/4885L3MBTL1 3930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.