Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | SPHK1 | Q9NYA1 | 8/20 | 0.55 |
| ▸ | SPHK2 | Q9NRA0 | 8/20 | 0.55 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16945678 | 0.88 | SPHK2 (0.69) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL16945676 | 0.88 | SPHK2 (0.69) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL1312572 | 0.83 | NPC1 (0.68) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL1312565 | 0.83 | NPC1 (0.68) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL1313667 | 0.82 | NPC1 (0.65) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL24326606 | 0.81 | RAB9A (1.00) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL6468865 | 0.81 | RAB9A (0.60) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL15186351 | 0.80 | NR1H4 (0.60) | NPC1RAB9ASPHK1SPHK2 | |
| SCHEMBL17014736 | 0.78 | CYP1A2 (0.74) | NPC1RAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL3128029 | 0.78 | RAB9A (0.68) | NPC1RAB9AL3MBTL1CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010033701-A2 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION (US) | 2010-03-25 | — | — | WO | disclosed |