Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.62 |
| ▸ | HTR2C | P28335 | 6/20 | 0.57 |
| ▸ | HTR2A | P28223 | 5/20 | 0.57 |
| ▸ | HTR2B | P41595 | 5/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 9/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 9/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 9/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 9/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18452843 | 1.00 | HRH3 (0.62) | HRH3HTR2CHTR2AHTR2BCHRNB2 | |
| SCHEMBL13178304 | 0.85 | HRH3 (0.61) | HRH3HTR2CHTR2AHTR2BCHRNB2 | |
| SCHEMBL13178393 | 0.85 | HRH3 (0.61) | HRH3HTR2CHTR2AHTR2BCHRNB2 | |
| SCHEMBL18488412 | 0.85 | HTR2C (0.68) | HRH3HTR2CHTR2AHTR2BCHRNB2 | |
| SCHEMBL18452851 | 0.85 | HTR2C (0.68) | HRH3HTR2CHTR2AHTR2BCHRNB2 | |
| SCHEMBL6213136 | 0.84 | HTR2C (0.68) | HRH3HTR2CHTR2AHTR2BCHRNB2 | |
| SCHEMBL20463893 | 0.84 | CHRNB2 (0.65) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL21117803 | 0.84 | CHRNB2 (0.65) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL18451623 | 0.84 | HRH3 (0.57) | HRH3HTR2CHTR2AHTR2BCHRNB2 | |
| SCHEMBL18451630 | 0.83 | HTR2C (0.70) | HRH3HTR2CHTR2AHTR2BCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399468-B2 | Octahydro-pyrrolo[3,4-B]pyrrole derivatives | ABBOTT LABORATORIES (US) | 2013-03-19 | — | — | US | disclosed |
| US-20100222358-A1 | OCTAHYDRO-PYRROLO[3,4-B]PYRROLE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-09-02 | — | — | US | disclosed |
| US-7728031-B2 | Octahydro-pyrrolo[3,4-b]pyrrole derivatives | ABBOTT LABORATORIES (US) | 2010-06-01 | — | — | US | disclosed |
| US-20070232612-A1 | Octahydro-pyrrolo[3,4-b]pyrrole Derivatives | ABBVIE INC. | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222358-A1 | OCTAHYDRO-PYRROLO[3,4-B]PYRROLE DERIVATIVES | HRH4, HRH2, TAC3 | HRH3 4/4885HTR2C 121/4885HTR2A 231/4885 |
| US-20070232612-A1 | Octahydro-pyrrolo[3,4-b]pyrrole Derivatives | HRH4, HRH2, TAC3 | HRH3 5/4885HTR2C 124/4885HTR2A 246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.