Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | BDKRB1 | P46663 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA7 | P43166 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14437211 | 0.80 | TRPV1 (0.48) | LMNAALDH1A1HTR1ADRD2HTR2A | |
| SCHEMBL31371415 | 0.80 | TRPV1 (0.48) | LMNAALDH1A1HTR1ADRD2HTR2A | |
| SCHEMBL1787459 | 0.80 | CYP11B2 (0.56) | LMNAALDH1A1L3MBTL1HTR1AHTR2A | |
| SCHEMBL21178333 | 0.79 | DRD2 (0.52) | LMNAALDH1A1L3MBTL1DRD2BDKRB1 | |
| SCHEMBL5267967 | 0.79 | DRD2 (0.52) | LMNAALDH1A1L3MBTL1DRD2BDKRB1 | |
| SCHEMBL4049287 | 0.79 | DRD2 (0.52) | LMNAALDH1A1L3MBTL1DRD2BDKRB1 | |
| SCHEMBL31130047 | 0.79 | DRD2 (0.52) | LMNAALDH1A1L3MBTL1DRD2BDKRB1 | |
| SCHEMBL22371926 | 0.79 | TRPV1 (0.41) | LMNAALDH1A1L3MBTL1CA12CA1 | |
| SCHEMBL20843687 | 0.79 | TRPV1 (0.41) | LMNAALDH1A1L3MBTL1CA12CA1 | |
| SCHEMBL8251946 | 0.78 | CA12 (0.44) | LMNAALDH1A1HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION | 2011-11-10 | — | — | US | disclosed |
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | SPHK1, SPHK2, S1PR1 | LMNA 2971/4885ALDH1A1 1495/4885L3MBTL1 3930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.