Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13148398 | 0.82 | ALDH1A1 (0.41) | CYP19A1KMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL577826 | 0.81 | SRC (0.36) | SRCCDK2ZAP70SYKCYP19A1 | |
| SCHEMBL13147763 | 0.75 | KDM4E (0.39) | CYP19A1KMT2AMEN1NPC1POLB | |
| SCHEMBL13147614 | 0.75 | EIF4E (0.41) | CYP19A1 | |
| SCHEMBL13147344 | 0.75 | PLA2G10 (0.36) | CYP19A1 | |
| SCHEMBL13147628 | 0.74 | KDM4A (0.38) | CYP19A1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL13147630 | 0.72 | FGFR3 (0.41) | — | |
| SCHEMBL13147629 | 0.72 | IDO1 (0.42) | CYP19A1 | |
| SCHEMBL13147340 | 0.71 | ALDH1A1 (0.36) | CYP19A1KMT2AMEN1ALDH1A1 | |
| SCHEMBL13147691 | 0.71 | HTR7 (0.33) | CYP19A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118078-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |