Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | SDHB | P21912 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 4/20 | 0.41 |
| ▸ | IDH2 | P48735 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13147678 | 0.88 | MAPT (0.54) | PRMT6MAPTALDH1A1SMN1; SMN2IDH1 | |
| SCHEMBL13147663 | 0.87 | SMN1; SMN2 (0.56) | PRMT6MAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL578404 | 0.86 | MAPT (0.47) | PRMT6MAPTALDH1A1SMN1; SMN2SDHB | |
| SCHEMBL577945 | 0.83 | MAPT (0.47) | MAPTALDH1A1SMN1; SMN2SDHBMEN1 | |
| SCHEMBL13147685 | 0.80 | SMN1; SMN2 (0.44) | PRMT6MAPTALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL577847 | 0.78 | PRMT6 (0.40) | PRMT6MAPTALDH1A1SMN1; SMN2SDHB | |
| SCHEMBL577980 | 0.74 | KDM4E (0.52) | MAPTALDH1A1SMN1; SMN2IDH1IDH2 | |
| SCHEMBL578368 | 0.73 | MAPT (0.58) | MAPTALDH1A1SMN1; SMN2IDH1IDH2 | |
| SCHEMBL13719485 | 0.73 | IDH1 (0.51) | PRMT6MAPTALDH1A1SMN1; SMN2IDH1 | |
| SCHEMBL578010 | 0.73 | ALDH1A1 (0.56) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118078-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |