Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 11/20 | 0.71 |
| ▸ | USP2 | O75604 | 7/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.66 |
| ▸ | HPGDS | O60760 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | NAMPT | P43490 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MGLL | Q99685 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13148048 | 0.89 | HPGDS (0.74) | CYP3A4USP2SMN1; SMN2CYP1A2HPGDS | |
| SCHEMBL13148140 | 0.88 | CYP3A4 (0.71) | CYP3A4USP2SMN1; SMN2CYP1A2HPGDS | |
| SCHEMBL13148237 | 0.86 | HPGDS (0.64) | CYP3A4USP2SMN1; SMN2CYP1A2HPGDS | |
| SCHEMBL13148160 | 0.85 | CYP3A4 (0.71) | CYP3A4USP2SMN1; SMN2CYP1A2HPGDS | |
| SCHEMBL13148296 | 0.85 | HPGDS (0.80) | CYP3A4USP2SMN1; SMN2CYP1A2HPGDS | |
| SCHEMBL13148152 | 0.84 | CYP3A4 (0.71) | CYP3A4USP2SMN1; SMN2CYP1A2HPGDS | |
| SCHEMBL3086645 | 0.83 | CYP3A4 (0.68) | CYP3A4USP2SMN1; SMN2CYP1A2HPGDS | |
| SCHEMBL13148282 | 0.83 | HPGDS (0.73) | CYP3A4USP2SMN1; SMN2CYP1A2HPGDS | |
| SCHEMBL13148144 | 0.82 | CYP3A4 (0.86) | CYP3A4USP2SMN1; SMN2CYP1A2HPGDS | |
| SCHEMBL3076704 | 0.81 | HPGDS (0.74) | CYP3A4USP2SMN1; SMN2CYP1A2HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234377-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | EVOTEC AG (DE) | 2010-09-16 | — | — | US | disclosed |
| US-20100234377-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | EVOTEC AG (DE) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234377-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | HPGDS, PTGDR, PTGIS | CYP3A4 2577/4885USP2 3860/4885SMN1; SMN2 1866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.