Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL696292 | 0.91 | MAP2K1 (0.56) | MAP2K1MAP2K2LDHA | |
| SCHEMBL696857 | 0.84 | MAP2K1 (0.55) | MAP2K1MAP2K2LDHA | |
| SCHEMBL694662 | 0.81 | MAP2K1 (0.60) | MAP2K1MAP2K2 | |
| SCHEMBL695617 | 0.81 | MAP2K1 (0.53) | MAP2K1MAP2K2LDHA | |
| SCHEMBL696463 | 0.81 | MAP2K1 (0.59) | MAP2K1MAP2K2 | |
| SCHEMBL698524 | 0.80 | MAP2K1 (0.52) | MAP2K1MAP2K2LDHA | |
| SCHEMBL698475 | 0.80 | MAP2K1 (0.55) | MAP2K1MAP2K2 | |
| SCHEMBL13148371 | 0.80 | MAP2K1 (0.52) | MAP2K1MAP2K2 | |
| SCHEMBL693613 | 0.79 | ALDH1A1 (0.54) | MAP2K1MAP2K2 | |
| SCHEMBL696164 | 0.79 | MAP2K1 (0.60) | MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010121646-A1 | HETEROCYCLIC COMPOUNDS AS MEK INHIBITORS | NOVARTIS AG (CH) | 2010-10-28 | — | — | WO | disclosed |