Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 12/20 | 0.50 |
| ▸ | MAP2K2 | P36507 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13613786 | 0.97 | MAP2K1 (0.53) | MAP2K1MAP2K2KDM4EALDH1A1KMT2A | |
| SCHEMBL693420 | 0.87 | MAP2K1 (0.50) | MAP2K1MAP2K2ALDH1A1KMT2ANPC1 | |
| SCHEMBL693328 | 0.83 | MAP2K1 (0.69) | MAP2K1MAP2K2 | |
| SCHEMBL694244 | 0.83 | MAP2K1 (0.53) | MAP2K1MAP2K2ALDH1A1KMT2ANPC1 | |
| SCHEMBL697510 | 0.83 | MAP2K1 (0.53) | MAP2K1ALDH1A1KMT2AMEN1 | |
| SCHEMBL13148370 | 0.81 | MAP2K1 (0.59) | MAP2K1MAP2K2RAB9A | |
| SCHEMBL697699 | 0.81 | MAP2K1 (0.52) | MAP2K1MAP2K2KDM4EALDH1A1KMT2A | |
| SCHEMBL13148456 | 0.81 | MAP2K1 (0.55) | MAP2K1MAP2K2KDM4EALDH1A1KMT2A | |
| SCHEMBL693613 | 0.78 | ALDH1A1 (0.54) | MAP2K1MAP2K2ALDH1A1KMT2AMEN1 | |
| SCHEMBL692982 | 0.77 | ALDH1A1 (0.43) | MAP2K1MAP2K2KDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010121646-A1 | HETEROCYCLIC COMPOUNDS AS MEK INHIBITORS | NOVARTIS AG (CH) | 2010-10-28 | — | — | WO | disclosed |