Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.73 |
| ▸ | MAPT | P10636 | 8/20 | 0.59 |
| ▸ | LMNA | P02545 | 6/20 | 0.59 |
| ▸ | HTT | P42858 | 5/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6301912 | 0.91 | ALDH1A1 (0.79) | ALDH1A1SMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL14633632 | 0.91 | ALDH1A1 (0.79) | ALDH1A1SMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL6297678 | 0.86 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL6819562 | 0.85 | KMT2A (0.72) | ALDH1A1SMN1; SMN2MAPTHTTGAA | |
| SCHEMBL458335 | 0.84 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL1311708 | 0.84 | MEN1 (0.82) | ALDH1A1SMN1; SMN2MAPTLMNANPC1 | |
| SCHEMBL4050791 | 0.84 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL5078630 | 0.84 | ALDH1A1 (0.79) | ALDH1A1SMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL7642168 | 0.83 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL30542215 | 0.83 | MEN1 (0.80) | ALDH1A1SMN1; SMN2MAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385831-A2 | SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT | The UAB Research Foundation (US) | 2011-11-16 | — | — | EP | claimed |
| US-20110254866-A1 | INFORMATION PROCESSING APPARATUS, METHOD AND PROGRAM THEREFORE | SONY CORPORATION (JP) | 2011-10-20 | — | — | US | claimed |
| WO-2010123591-A2 | SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT | THE UAB RESEARCH FOUNDATION (US) | 2010-10-28 | — | — | WO | claimed |
| EP-2385831-A2 | SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT | The UAB Research Foundation (US) | 2011-11-16 | — | — | EP | disclosed |
| US-20110275635-A1 | SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT | THE UAB RESEARCH FOUNDATION (US) | 2011-11-10 | — | — | US | disclosed |
| US-20110254866-A1 | INFORMATION PROCESSING APPARATUS, METHOD AND PROGRAM THEREFORE | SONY CORPORATION (JP) | 2011-10-20 | — | — | US | disclosed |
| WO-2010123591-A2 | SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT | THE UAB RESEARCH FOUNDATION (US) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275635-A1 | SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT | NAMPT, NAPRT, NNT | ALDH1A1 1835/4885SMN1; SMN2 3153/4885MAPT 833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.