Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | ICMT | O60725 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14467116 | 0.94 | NSD2 (0.43) | KDRTP53HPGDSRCKCNH2 | |
| SCHEMBL13152447 | 0.93 | HPGD (0.45) | KDRTP53HPGDSRCKCNH2 | |
| SCHEMBL10097432 | 0.91 | MAPT (0.45) | KDRTP53HPGDSRCKCNH2 | |
| SCHEMBL10251510 | 0.89 | KDR (0.39) | KDRTP53SRCMAPTALDH1A1 | |
| SCHEMBL10097620 | 0.89 | ALDH1A1 (0.43) | TP53HPGDSRCKCNH2CNR2 | |
| SCHEMBL10097465 | 0.89 | RAB9A (0.57) | KDRTP53MAPTMEN1KMT2A | |
| SCHEMBL13151807 | 0.88 | TP53 (0.47) | TP53HPGDSRCKCNH2CNR2 | |
| SCHEMBL12950382 | 0.88 | MAPT (0.42) | KDRTP53HPGDMAPTALDH1A1 | |
| SCHEMBL10096424 | 0.88 | NSD2 (0.43) | KDRTP53HPGDSRCKCNH2 | |
| SCHEMBL13152378 | 0.87 | MEN1 (0.43) | TP53HPGDSRCKCNH2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
| WO-2007084435-A2 | METHODS FOR TREATING HEPATITIS C | PTC THERAPEUTICS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |