Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK2 | Q13002 | 2/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13152063 | 0.93 | MTNR1B (0.51) | GRIK2MTNR1BMTNR1AKMT2ANPC1 | |
| SCHEMBL10095684 | 0.87 | GRIK2 (0.46) | GRIK2MTNR1BMTNR1AKMT2ANPC1 | |
| SCHEMBL13152139 | 0.86 | MTNR1B (0.48) | GRIK2MTNR1BMTNR1AKMT2ANPC1 | |
| SCHEMBL13152066 | 0.85 | GRIK2 (0.45) | GRIK2MTNR1BMTNR1AKMT2ANPC1 | |
| SCHEMBL13152069 | 0.85 | ITGB3 (0.47) | GRIK2MTNR1BMTNR1AKMT2ANPC1 | |
| SCHEMBL13152572 | 0.85 | MTNR1B (0.49) | GRIK2MTNR1BMTNR1AKMT2ANPC1 | |
| SCHEMBL13152067 | 0.84 | GRIK2 (0.42) | GRIK2MTNR1BMTNR1AKMT2ANPC1 | |
| SCHEMBL13152096 | 0.84 | KMT2A (0.46) | GRIK2MTNR1BMTNR1AKMT2ANPC1 | |
| SCHEMBL10249317 | 0.83 | GSK3A (0.49) | KMT2ANPC1MEN1RAB9AMAPT | |
| SCHEMBL10097283 | 0.83 | TSHR (0.47) | GRIK2KMT2ANPC1MEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |