Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10097644 | 0.95 | MAPT (0.45) | MAPTHPGDKMT2AALDH1A1MEN1 | |
| SCHEMBL14467118 | 0.93 | MAPT (0.42) | MAPTHPGDKMT2AALDH1A1MEN1 | |
| SCHEMBL13152128 | 0.93 | ALDH1A1 (0.42) | MAPTHPGDKMT2AALDH1A1MEN1 | |
| SCHEMBL10097769 | 0.90 | KMT2A (0.52) | MAPTKMT2ATP53NPC1LMNA | |
| SCHEMBL10097724 | 0.89 | ALDH1A1 (0.47) | MAPTKMT2AALDH1A1MEN1TP53 | |
| SCHEMBL13152653 | 0.87 | MAPT (0.41) | MAPTHPGDKMT2AALDH1A1MEN1 | |
| SCHEMBL10096384 | 0.86 | ADRB1 (0.42) | MAPTHPGDKMT2AALDH1A1MEN1 | |
| SCHEMBL12108935 | 0.86 | MAPT (0.45) | MAPTHPGDKMT2AALDH1A1TP53 | |
| SCHEMBL13152654 | 0.86 | HPGD (0.41) | MAPTHPGDKMT2AALDH1A1MEN1 | |
| SCHEMBL13152494 | 0.86 | NPC1 (0.44) | MAPTHPGDKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
| WO-2007084435-A2 | METHODS FOR TREATING HEPATITIS C | PTC THERAPEUTICS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |