Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PRKDC | P78527 | 2/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PDE9A | O76083 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13153363 | 0.94 | PIK3CA (0.35) | PIK3CAPRKDCSTSHTR3AMEN1 | |
| SCHEMBL13151969 | 0.94 | HTR3A (0.36) | PIK3CAPRKDCSTSNPSR1HTR3A | |
| SCHEMBL12950295 | 0.93 | STS (0.35) | PIK3CAPRKDCSTSNPSR1HTR3A | |
| SCHEMBL13053607 | 0.87 | AXL (0.34) | STSNPSR1 | |
| SCHEMBL14467708 | 0.87 | HTR3A (0.33) | PIK3CAPRKDCSTSHTR3AMTOR | |
| SCHEMBL10096738 | 0.86 | PIK3CA (0.34) | PIK3CAPRKDCSTSNPSR1HTR3A | |
| SCHEMBL10097537 | 0.85 | PIK3CA (0.36) | PIK3CAPRKDCHTR3AMEN1KMT2A | |
| SCHEMBL13151683 | 0.84 | PIK3CA (0.36) | PIK3CAPRKDCMEN1KMT2AMAPT | |
| SCHEMBL13151681 | 0.84 | LMNA (0.42) | PIK3CAPRKDCMEN1KMT2AMAPT | |
| SCHEMBL13153361 | 0.84 | TDP1 (0.40) | PIK3CAPRKDCMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
| WO-2007084435-A2 | METHODS FOR TREATING HEPATITIS C | PTC THERAPEUTICS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |