Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.52 |
| ▸ | SMURF1 | Q9HCE7 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13158358 | 0.90 | TP53 (0.55) | TP53PTGS2LMNAHSP90AA1MAPT | |
| SCHEMBL13158347 | 0.89 | TP53 (0.64) | TP53PTGS2LMNAHSP90AA1MAPT | |
| SCHEMBL13158359 | 0.88 | KMT2A (0.56) | TP53SMURF1LMNAPOLBMAPT | |
| SCHEMBL13158458 | 0.87 | PTGS2 (0.52) | TP53PTGS2SMURF1MAPTNPC1 | |
| SCHEMBL5243957 | 0.85 | ROCK1 (0.46) | LMNAMAPTKDM4EMEN1NPC1 | |
| SCHEMBL13158422 | 0.84 | TP53 (0.52) | TP53PTGS2SMURF1LMNAHSP90AA1 | |
| SCHEMBL13158460 | 0.83 | RAB9A (0.53) | TP53PTGS2SMURF1MAPTNPC1 | |
| SCHEMBL13158427 | 0.83 | PTGS2 (0.49) | TP53PTGS2SMURF1MAPTNPC1 | |
| SCHEMBL13158410 | 0.83 | TP53 (0.51) | TP53PTGS2SMURF1LMNAHSP90AA1 | |
| SCHEMBL13158351 | 0.83 | TP53 (0.51) | TP53PTGS2SMURF1LMNAHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803822-B2 | Triazole derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-28 | — | — | US | disclosed |
| US-20090105253-A1 | Triazole Derivative and Use Thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105253-A1 | Triazole Derivative and Use Thereof | F2R, HRH4, F2RL3 | TP53 2716/4885PTGS2 1750/4885SMURF1 4730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.