Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.55 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.50 |
| ▸ | HAT1 | O14929 | 2/20 | 0.48 |
| ▸ | EP300 | Q09472 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.44 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2584852 | 0.98 | NPC1 (0.57) | NPC1RAB9AEPHB3SLC27A1HAT1 | |
| SCHEMBL12641490 | 0.84 | NPC1 (0.55) | NPC1RAB9AEPHB3SLC27A1HAT1 | |
| SCHEMBL12789990 | 0.84 | RAB9A (0.55) | NPC1RAB9AEPHB3SLC27A1HAT1 | |
| SCHEMBL6112768 | 0.84 | NPC1 (0.55) | NPC1RAB9AEPHB3SLC27A1HAT1 | |
| SCHEMBL20434869 | 0.84 | NPC1 (0.55) | NPC1RAB9AEPHB3SLC27A1HAT1 | |
| SCHEMBL13984885 | 0.84 | NPC1 (0.55) | NPC1RAB9AEPHB3SLC27A1HAT1 | |
| SCHEMBL14743372 | 0.81 | NPC1 (0.63) | NPC1RAB9AEPHB3SLC27A1HAT1 | |
| Hydrochloric Acid SCHEMBL14746375 | 0.80 | NPC1 (0.61) | NPC1RAB9AEPHB3SLC27A1HAT1 | |
| SCHEMBL496758 | 0.80 | NPC1 (0.60) | NPC1RAB9AEPHB3SLC27A1HAT1 | |
| Hydrochloric Acid SCHEMBL21834227 | 0.78 | NPC1 (0.59) | NPC1RAB9AEPHB3SLC27A1HAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110590785-B | Aminothiazole compound, preparation method thereof and application of aminothiazole compound in resisting enterovirus 71 | 武汉大学 | 2021-02-02 | — | — | CN | disclosed |
| CN-110590785-A | Aminothiazole compound, preparation method thereof and application of aminothiazole compound in resisting enterovirus 71 | 武汉大学 | 2019-12-20 | — | — | CN | disclosed |
| EP-1418909-B1 | 2-AMINO-4, 5-TRISUBSTITUTED THIAzOLYL DERIVATIVES AND THEIR USE AGAINST AUTOIMMUNE DISEASES | JANSSEN PHARMACEUTICA NV (BE) | 2013-02-20 | — | — | EP | disclosed |
| US-7803823-B2 | 2-amino-4,5-trisubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-28 | — | — | US | disclosed |
| US-7803823-B2 | 2-amino-4,5-trisubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-28 | — | — | US | disclosed |
| US-20070203189-A1 | 2-Amino-4,5-Trisubstituted Thiazolyl Derivatives | LOVE CHRISTOPHER J | 2007-08-30 | — | — | US | disclosed |
| US-20070203189-A1 | 2-Amino-4,5-Trisubstituted Thiazolyl Derivatives | LOVE CHRISTOPHER J | 2007-08-30 | — | — | US | disclosed |
| US-7232838-B2 | 2-amino-4,5-trisubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-06-19 | — | — | US | disclosed |
| US-7232838-B2 | 2-amino-4,5-trisubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203189-A1 | 2-Amino-4,5-Trisubstituted Thiazolyl Derivatives | IFNG, IL15, IL5 | NPC1 1283/4885RAB9A 3927/4885EPHB3 4633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.