Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12158250 | 0.84 | MAPT (0.61) | MAPTMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL13159787 | 0.83 | CHRNA7 (0.52) | MAPTMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL12174571 | 0.80 | KIF11 (0.53) | MAPTMEN1KMT2AADORA2AADORA2B | |
| SCHEMBL13159790 | 0.79 | MEN1 (0.55) | MAPTMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL12158002 | 0.74 | GAA (0.51) | MAPTMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL1850222 | 0.72 | ADORA2A (0.54) | MAPTMEN1KMT2ASMN1; SMN2ADORA2A | |
| SCHEMBL19638026 | 0.72 | ADORA2A (0.53) | MEN1KMT2ARAB9AADORA2AADORA2B | |
| SCHEMBL18083891 | 0.71 | MEN1 (1.00) | MAPTMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL12158108 | 0.71 | GAA (0.53) | MAPTMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL21283312 | 0.70 | ADORA1 (0.49) | MAPTSMN1; SMN2ADORA2AADORA2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1418909-B1 | 2-AMINO-4, 5-TRISUBSTITUTED THIAzOLYL DERIVATIVES AND THEIR USE AGAINST AUTOIMMUNE DISEASES | JANSSEN PHARMACEUTICA NV (BE) | 2013-02-20 | — | — | EP | disclosed |
| US-7803823-B2 | 2-amino-4,5-trisubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-28 | — | — | US | disclosed |
| US-7803823-B2 | 2-amino-4,5-trisubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-28 | — | — | US | disclosed |
| US-20070203189-A1 | 2-Amino-4,5-Trisubstituted Thiazolyl Derivatives | LOVE CHRISTOPHER J | 2007-08-30 | — | — | US | disclosed |
| US-20070203189-A1 | 2-Amino-4,5-Trisubstituted Thiazolyl Derivatives | LOVE CHRISTOPHER J | 2007-08-30 | — | — | US | disclosed |
| US-7232838-B2 | 2-amino-4,5-trisubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-06-19 | — | — | US | disclosed |
| US-7232838-B2 | 2-amino-4,5-trisubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203189-A1 | 2-Amino-4,5-Trisubstituted Thiazolyl Derivatives | IFNG, IL15, IL5 | MAPT 3417/4885MEN1 3768/4885KMT2A 3207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.