Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18904288 | 0.89 | CHRNA7 (0.63) | CHRNA7DHODHIDH2CCNA2CDK2 | |
| SCHEMBL12158257 | 0.87 | CHRNA7 (0.78) | CHRNA7DHODHIDH2CCNA2CDK2 | |
| SCHEMBL13159796 | 0.84 | CHRNA7 (0.55) | CHRNA7DHODHIDH2CYP2D6CYP2C19 | |
| SCHEMBL12158245 | 0.84 | CHRNA7 (0.57) | CHRNA7DHODHIDH2CCNA2CDK2 | |
| SCHEMBL12157994 | 0.84 | CHRNA7 (0.58) | CHRNA7DHODHIDH2MAPTSMN1; SMN2 | |
| SCHEMBL4207949 | 0.83 | CHRNA7 (0.42) | CHRNA7ROCK2DHODHCYP2D6CYP2C19 | |
| SCHEMBL12158256 | 0.83 | CHRNA7 (0.55) | CHRNA7ROCK2CCNA2CDK2CCNA1 | |
| SCHEMBL12158251 | 0.82 | CHRNA7 (0.55) | CHRNA7DHODHIDH2CCNA2CDK2 | |
| SCHEMBL13159765 | 0.80 | CHRNA7 (0.52) | CHRNA7DHODHIDH2CCNA2CDK2 | |
| SCHEMBL13159787 | 0.80 | CHRNA7 (0.52) | CHRNA7DHODHIDH2CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1418909-B1 | 2-AMINO-4, 5-TRISUBSTITUTED THIAzOLYL DERIVATIVES AND THEIR USE AGAINST AUTOIMMUNE DISEASES | JANSSEN PHARMACEUTICA NV (BE) | 2013-02-20 | — | — | EP | disclosed |
| US-7803823-B2 | 2-amino-4,5-trisubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-28 | — | — | US | disclosed |
| US-7803823-B2 | 2-amino-4,5-trisubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-28 | — | — | US | disclosed |
| US-20070203189-A1 | 2-Amino-4,5-Trisubstituted Thiazolyl Derivatives | LOVE CHRISTOPHER J | 2007-08-30 | — | — | US | disclosed |
| US-20070203189-A1 | 2-Amino-4,5-Trisubstituted Thiazolyl Derivatives | LOVE CHRISTOPHER J | 2007-08-30 | — | — | US | disclosed |
| US-7232838-B2 | 2-amino-4,5-trisubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-06-19 | — | — | US | disclosed |
| US-7232838-B2 | 2-amino-4,5-trisubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203189-A1 | 2-Amino-4,5-Trisubstituted Thiazolyl Derivatives | IFNG, IL15, IL5 | CHRNA7 1921/4885ROCK2 2172/4885DHODH 2976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.