SCHEMBL13161

SCHEMBL13161

O=C1CCCN1CCN1CCCCC1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.58
CHRM2 P08172 2/20 0.56
CHRM4 P08173 2/20 0.56
CHRM5 P08912 2/20 0.56
CHRM1 P11229 2/20 0.56
CHRM3 P20309 2/20 0.56
CYP1A2 P05177 1/20 0.56
CYP2D6 P10635 1/20 0.56
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
ADRA1D P25100 2/20 0.54
ADRA1A P35348 2/20 0.54
ADRA1B P35368 2/20 0.54
HRH3 Q9Y5N1 1/20 0.49
PIK3CD O00329 1/20 0.47
MEN1 O00255 1/20 0.46
PKM P14618 1/20 0.46
TSHR P16473 1/20 0.46
BLM P54132 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13073467 0.98 CHRM2 (0.58) KMT2ACHRM2CHRM4CHRM5CHRM1
SCHEMBL261644 0.87 PIK3CD (0.58) KMT2ACHRM2CHRM4CHRM5CHRM1
SCHEMBL11728588 0.86 ADRA1B (0.56) KMT2ACHRM2CHRM4CHRM5CHRM1
SCHEMBL7265729 0.86 CYP1A2 (0.55) KMT2ACHRM2CHRM4CHRM5CHRM1
SCHEMBL19539137 0.84 ADRA1B (0.55) KMT2ACHRM2CHRM4CHRM5CHRM1
SCHEMBL16364962 0.82 ADRA1B (0.50) KMT2ACHRM2CHRM4CHRM5CHRM1
SCHEMBL5531197 0.82 KMT2A (0.53) KMT2ACHRM2CHRM4CHRM5CHRM1
SCHEMBL11577651 0.81 ADRA1D (0.46) KMT2ACHRM2CHRM4CHRM5CHRM1
SCHEMBL21001577 0.81 CYP1A2 (0.50) KMT2ACHRM2CHRM4CHRM5CHRM1
SCHEMBL1778659 0.81 KMT2A (0.82) KMT2ACHRM2CHRM4CHRM5CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011058149-A1 TRICYCLIC PYRAZOL AMINE DERIVATIVES MERCK SERONO S.A. (CH) 2011-05-19 WO disclosed